The effects of antihypertensive drugs on the choroidal blood flow in rabbits were studied by an apparatus based on the principle of internal calorimetry of Grayson.
Thermistors, as the sensing elements, were fastened on the scleral surface of the eye, and determinations were performed up to 60 minutes after intravenous administrations of drugs.
The drugs studied were:
ganglion blocking agents (pentholinium tartarate, 4mg; hexamethonium bromide, 1mg; and mecaznylamine chloride, 0.15mg),
alpha-methyldopa, 4 mg; guanethidine, 0.5 mg; reserpine, 0.2 mg; hydralazine, 5 mg; and diuretics ,(dichlorothiazide, 2.5 mg; frusemide, 2.5 mg).
Except the diuretics, all the drugs employed produced considerable increase in the choroidal blood flow,
The relationships between blood pressure, intraocular pressure and the choroidal blood flow were discussed and the clinical applications were suggested.
|